7-Hydroxy-3-(4-methoxyphenyl)-4-methyl-2H-1-benzopyran-2-one → 3,4-Dihydro-2H-quinoline-1-carboxylic Acid 3-(4-methoxy-phenyl)-4-methyl-2-oxo-2H-chromen-7-yl Ester

HRID 1831145Notes

Reaction equation

HRID 1831145 reaction equation
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:21])=[C:7]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=3)[C:8](=[O:12])[O:9]2)=[CH:4][CH:3]=1.[I-].[N:23]1([C:33](N2C=C[N+](C)=C2)=[O:34])[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[CH2:26][CH2:25][CH2:24]1>>[CH3:20][O:19][C:16]1[CH:17]=[CH:18][C:13]([C:7]2[C:8](=[O:12])[O:9][C:10]3[C:5]([C:6]=2[CH3:21])=[CH:4][CH:3]=[C:2]([O:1][C:33]([N:23]2[C:32]4[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=4)[CH2:26][CH2:25][CH2:24]2)=[O:34])[CH:11]=3)=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 53576277-Hydroxy-3-(4-methoxyphenyl)-4-methyl-2H-1-benzopyran-2-oneHCID 10959576HCID 10959576, compound

Product 1

HCID 865891983,4-Dihydro-2H-quinoline-1-carboxylic Acid 3-(4-methoxy-phenyl)-4-methyl-2-oxo-2H-chromen-7-yl EsterYield 59%

Procedure

The title compound (130 mg, 59% yield, white solid) was prepared from 7-hydroxy-3-(4-methoxy-phenyl)-4-methyl-chromen-2-one (141 mg, 0.50 mmol) and 3-(3,4-dihydro-2H-quinoline-1-carbonyl)-1-methyl-3H-imidazol-1-ium iodide (188 mg, 0.51 mmol).

Sources & evidence

ORD record
ord-e7f1d6c6f619410797f27613a2c33a20
Source dataset
uspto-grants-2006_06
Patent number
US07067517B2

Reaction notes

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