HCID 6217099, compound → 3,4-Dihydro-2H-quinoline-1-carboxylic Acid 3-(2,5-dimethoxy-phenyl)-4-methyl-2-oxo-2H-chromen-7-yl Ester

HRID 1831147Notes

Reaction equation

HRID 1831147 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[C:11]1[C:12](=[O:23])[O:13][C:14]2[C:19]([C:20]=1[CH3:21])=[CH:18][CH:17]=[C:16]([OH:22])[CH:15]=2.[I-].[N:25]1([C:35](N2C=C[N+](C)=C2)=[O:36])[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH2:28][CH2:27][CH2:26]1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[C:11]1[C:12](=[O:23])[O:13][C:14]2[C:19]([C:20]=1[CH3:21])=[CH:18][CH:17]=[C:16]([O:22][C:35]([N:25]1[C:34]3[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=3)[CH2:28][CH2:27][CH2:26]1)=[O:36])[CH:15]=2

Participants

3

Reactant 2

HCID 6217099HCID 6217099, compoundHCID 109595761-(3,4-Dihydroquinolin-1(2H)-ylcarbonyl)-3-methyl-1H-imidazol-3-ium Iodide

Product 1

HCID 865892003,4-Dihydro-2H-quinoline-1-carboxylic Acid 3-(2,5-dimethoxy-phenyl)-4-methyl-2-oxo-2H-chromen-7-yl EsterYield 21.2%

Procedure

The title compound (50 mg, 21% yield, white solid) was prepared from 3-(2,5-dimethoxy-phenyl)-7-hydroxy-4-methyl-chromen-2-one (156 mg, 0.50 mmol) and 3-(3,4-dihydro-2H-quinoline-1-carbonyl)-1-methyl-3H-imidazol-1-ium iodide (188 mg, 0.51 mmol).

Sources & evidence

ORD record
ord-53133897d36149a99a7e8d5fa06f54d2
Source dataset
uspto-grants-2006_06
Patent number
US07067517B2

Reaction notes

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