4-Morpholinecarbonyl chloride → HCID 23635512, compound

HRID 1831150Notes

Reaction equation

HRID 1831150 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:4]=[CH:5][C:6]([O:9][C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)=[N:7][CH:8]=1.[N:19]1([C:25](Cl)=[O:26])[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1>>[F:18][C:2]([F:1])([F:17])[C:3]1[CH:4]=[CH:5][C:6]([O:9][C:10]2[CH:11]=[CH:12][C:13]([O:16][C:25]([N:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)=[O:26])=[CH:14][CH:15]=2)=[N:7][CH:8]=1

Participants

3

Reactant 2

HCID 848104-Morpholinecarbonyl chlorideHCID 1552414-(5-Trifluoromethyl-pyridin-2-yloxy)-phenol

Product 1

HCID 23635512HCID 23635512, compound

Procedure

The title compound was prepared from 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenol and morpholine-4-carbonyl chloride. The crude product was purified by preparative HPLC (37%, white crystals). HPLC-MS m/z=369.1 (M+1), Rt: 4.3 min.

Workup

  1. customThe crude product was purified by preparative HPLC (37%, white crystals)

Sources & evidence

ORD record
ord-141fd94896ed4603a617d3a42ce392d3
Source dataset
uspto-grants-2006_06
Patent number
US07067517B2

Reaction notes

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