N-Methylbutylamine → Methyl-phenyl-carbamic Acid 4-(butyl-methyl-carbamoyl)-phenyl Ester

HRID 1831213Notes

Reaction equation

HRID 1831213 reaction equation
O=C1CCC(=O)N1O[C:9](=[O:27])[C:10]1[CH:15]=[CH:14][C:13]([O:16][C:17](=[O:26])[N:18]([CH3:25])[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:12][CH:11]=1.[CH2:28]([NH:32][CH3:33])[CH2:29][CH2:30][CH3:31]>>[CH2:28]([N:32]([CH3:33])[C:9]([C:10]1[CH:11]=[CH:12][C:13]([O:16][C:17](=[O:26])[N:18]([CH3:25])[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)=[CH:14][CH:15]=1)=[O:27])[CH2:29][CH2:30][CH3:31]

Participants

3

Reactant 2

HCID 8068N-MethylbutylamineHCID 865892064-(Methyl-phenyl-carbamoyloxy)-benzoic Acid 2,5-dioxo-pyrrolidin-1-yl Ester

Product 1

HCID 69519010Methyl-phenyl-carbamic Acid 4-(butyl-methyl-carbamoyl)-phenyl Ester

Procedure

The title product was prepared from 4-(methyl-phenyl-carbamoyloxy)-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester and n-butyl-methyl-amine. The crude product was subjected to preparative HPLC (20%, oil). HPLC-MS: m/z=341.2 (M+1); Rt: 3.96 min.

Sources & evidence

ORD record
ord-ec95b06ef6a24ec6ba6b1dbdec87c06e
Source dataset
uspto-grants-2006_06
Patent number
US07067517B2

Reaction notes

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