N-Methylbenzeneethanamine → Methyl-phenyl-carbamic Acid 4-(methyl-phenethyl-carbamoyl)-phenyl Ester

HRID 1831214Notes

Reaction equation

HRID 1831214 reaction equation
O=C1CCC(=O)N1O[C:9](=[O:27])[C:10]1[CH:15]=[CH:14][C:13]([O:16][C:17](=[O:26])[N:18]([CH3:25])[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:12][CH:11]=1.[CH3:28][NH:29][CH2:30][CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>>[CH3:28][N:29]([CH2:30][CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[C:9]([C:10]1[CH:11]=[CH:12][C:13]([O:16][C:17](=[O:26])[N:18]([CH3:25])[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)=[CH:14][CH:15]=1)=[O:27]

Participants

3

Reactant 2

HCID 11503N-MethylbenzeneethanamineHCID 865892064-(Methyl-phenyl-carbamoyloxy)-benzoic Acid 2,5-dioxo-pyrrolidin-1-yl Ester

Product 1

HCID 69518284Methyl-phenyl-carbamic Acid 4-(methyl-phenethyl-carbamoyl)-phenyl Ester

Procedure

The title product was prepared from 4-(methyl-phenyl-carbamoyloxy)-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester and methyl-phenethyl-amine. The crude product was subjected to preparative HPLC (29%, oil). HPLC-MS: m/z=389.2 (M+1); Rt: 4.15 min.

Sources & evidence

ORD record
ord-18043a09d5c744ec9070132a990163ae
Source dataset
uspto-grants-2006_06
Patent number
US07067517B2

Reaction notes

Loading…