Cyclopropylamine → Methyl-phenyl-carbamic Acid 4-cyclopropylcarbamoyl-phenyl Ester

HRID 1831222Notes

Reaction equation

HRID 1831222 reaction equation
O=C1CCC(=O)N1O[C:9](=[O:27])[C:10]1[CH:15]=[CH:14][C:13]([O:16][C:17](=[O:26])[N:18]([CH3:25])[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:12][CH:11]=1.[CH:28]1([NH2:31])[CH2:30][CH2:29]1>>[CH:28]1([NH:31][C:9]([C:10]2[CH:11]=[CH:12][C:13]([O:16][C:17](=[O:26])[N:18]([CH3:25])[C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)=[CH:14][CH:15]=2)=[O:27])[CH2:30][CH2:29]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 865892064-(Methyl-phenyl-carbamoyloxy)-benzoic Acid 2,5-dioxo-pyrrolidin-1-yl Ester

Product 1

HCID 69517581Methyl-phenyl-carbamic Acid 4-cyclopropylcarbamoyl-phenyl Ester

Procedure

The title product was prepared from 4-(methyl-phenyl-carbamoyloxy)-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester and cyclopropylamine. The crude product was used without further purification (97%, oil). HPLC-MS: m/z=311.2 (M+1); Rt: 3.21 min.

Workup

  1. customThe crude product was used without further purification (97%, oil)

Sources & evidence

ORD record
ord-ffcb0d2fd58d41ed9006d5f5a977a37d
Source dataset
uspto-grants-2006_06
Patent number
US07067517B2

Reaction notes

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