1-(3,4-Dichlorophenyl)piperazine → HCID 69517535, compound

Participants

Reaction Steps

The hydrochloride of the title compound was prepared from 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate and 1-(3,4-dichlorophenyl)piperazine. The crude product was partitioned between dichlorormethane and 2 M aqueous sodium carbonate. The organic layer was washed with water, dried and evaporated. The residue was triturated with ethyl acetate-heptane (1:4) and the precipitate was collected by filtration and dried to give the title compound as white crystals. Yield 28%; m.p. 115–116° C.; 1H NMR (DMSO-d6): δ 8.61–8.55 (br, 1H), 8.30–8.20 (dd-like, 1H), 7.48–7.40 (d-like,1H), 7.31–7.16 (m, 6H), 7.04–6.94 (dd-like, 1H), 3.83–3.47 (br m, 4H), 3.36–3.24 (br s, 4H+water); HPLC-MS: m/z=512 (M+H); IR (KBr): ν 1724, 1706 cm−1.

Provenance & Evidence