1-(2-Chlorophenyl)piperazine → HCID 69518959, compound

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Reaction Steps

The the hydrochloride of title compound was prepared from 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate and 1-(2-chlorophenyl)piperazine. Drying in vacuo at 50° C. for 3½ h gave the title compound; 1H NMR (DMSO-d6): δ 8.61–8.55 (br, 1H), 8.29–8.20 (dd-like, 1H), 7.53–7.41 (m, 1H), 7.39–7.17 (m, 7H), 7.14–7.03 (m, 1H), 4.58 (br s, NH+water), 3.85–3.55 (br m, 4H), 3.12–2.99 (br m, 4H); HPLC-MS: m/z=478 (M+H); IR (KBr): ν 1733 (C═O) cm−1.

Provenance & Evidence