Carbamic chloride, N-methyl-N-phenyl- → HCID 10171977, compound

HRID 1831281Notes

Reaction equation

HRID 1831281 reaction equation
Cl.[OH:2][N:3]1[CH:7]=[CH:6][N:5]=[C:4]1[C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=1.[CH3:16][N:17]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:18](Cl)=[O:19]>>[CH3:15][O:14][C:11]1[CH:10]=[CH:9][C:8]([C:4]2[N:3]([O:2][C:18](=[O:19])[N:17]([CH3:16])[C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH:7]=[CH:6][N:5]=2)=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 77969Carbamic chloride, N-methyl-N-phenyl-HCID 131725812HCID 131725812, compound

Product 1

HCID 10171977HCID 10171977, compound

Procedure

The title compound was prepared from 1-hydroxy-2-(4-methoxyphenyl)imidazole, hydrochloride and N-methyl-N-phenylcarbamoyl chloride applying the general procedure 8. The crude product was purified by flash chromatography (Quad flash 12, EtOAc-heptane) (89%, crystals).

Workup

  1. customThe crude product was purified by flash chromatography (Quad flash 12, EtOAc-heptane) (89%, crystals)

Sources & evidence

ORD record
ord-2af06291440e4153aec49a4d50105c35
Source dataset
uspto-grants-2006_06
Patent number
US07067517B2

Reaction notes

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