4-Morpholinecarbonyl chloride → Morpholine-4-carboxylic Acid 3-(4-methoxy-phenyl)-pyrazol-1-yl Ester

HRID 1831301Notes

Reaction equation

HRID 1831301 reaction equation
[OH:1][N:2]1[CH:6]=[CH:5][C:4]([C:7]2[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][CH:8]=2)=[N:3]1.[N:15]1([C:21](Cl)=[O:22])[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1>>[CH3:14][O:13][C:10]1[CH:11]=[CH:12][C:7]([C:4]2[CH:5]=[CH:6][N:2]([O:1][C:21]([N:15]3[CH2:20][CH2:19][O:18][CH2:17][CH2:16]3)=[O:22])[N:3]=2)=[CH:8][CH:9]=1

Participants

3

Reactant 2

HCID 848104-Morpholinecarbonyl chlorideHCID 118055191-Hydroxy-3-(4-methoxyphenyl)pyrazole

Product 1

HCID 69518318Morpholine-4-carboxylic Acid 3-(4-methoxy-phenyl)-pyrazol-1-yl Ester

Procedure

The title compound was prepared from 1-hydroxy-3-(4-methoxyphenyl)pyrazole and 4-morpholine carbonyl chloride applying the general procedure 8. The crude product was purified by flash chromatography (Quad flash 12, EtOAc-heptane) (62%, crystals).

Workup

  1. customThe crude product was purified by flash chromatography (Quad flash 12, EtOAc-heptane) (62%, crystals)

Sources & evidence

ORD record
ord-fa55cf032550410998530371e7b7ef0a
Source dataset
uspto-grants-2006_06
Patent number
US07067517B2

Reaction notes

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