HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylamine → 4-Benzotriazol-1-yl-piperidine-1-carboxylic Acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylamine | HCID 7912 | — |
| Reactant | 1-(Piperidin-4-yl)-1H-benzotriazole--hydrogen chloride (1/1) | HCID 2779380 | — |
| Reactant | 4-(5-Trifluoromethylpyridin-2-yloxy)-phenyl chloroformate | HCID 22047762 | — |
| Product | 4-Benzotriazol-1-yl-piperidine-1-carboxylic Acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl Ester | HCID 69520407 | — |
Reaction Steps
The title compound was prepared from 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate and 1-piperidin-4-yl-1H-benzotriazole, hydrochloride, 5 equivalent of diisopropylamine was added, praeparative HPLC (Method C) (7%, colourless crystals). HPLC-MS m/z=506.2 (M+1), Rt: 4.56 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07067517B2 |
| Source dataset | uspto-grants-2006_06 |
| ORD ID | ord-6c9153c60a1042e0a77ca46e2f5153ab |
| Source note | uspto-grants-2006_06 |