Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylamine → 4-(Cyclopropyl-pyridin-4-ylmethyl-amino)-piperidine-1-carboxylic Acid 4-(5-trifluoromethylpyridin-2-yloxy)-phenyl Ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylamine | HCID 7912 | — |
| 반응물 | 4-(5-Trifluoromethylpyridin-2-yloxy)-phenyl chloroformate | HCID 22047762 | — |
| 반응물 | Cyclopropyl-piperidine-4-yl-pyridin-4-ylmethyl-amine | HCID 22047949 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-(Cyclopropyl-pyridin-4-ylmethyl-amino)-piperidine-1-carboxylic Acid 4-(5-trifluoromethylpyridin-2-yloxy)-phenyl Ester | HCID 69519442 | — |
반응 단계
The title product was prepared from cyclopropyl-piperidine-4-yl-pyridin-4-ylmethyl-amine and 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate, 3 equivalent of diisopropylamine was added, solvent: dimethylformamide. The crude reaction mixture was evaporated without addition of acetic acid, preparative HPLC (method C) (19%, yellow oil). HPLC-MS m/z=(M+1), Rt: 2.82 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07067517B2 |
| 출처 데이터셋 | uspto-grants-2006_06 |
| ORD ID | ord-8e21c401718140d4bb1930228b9b2215 |
| 출처 메모 | uspto-grants-2006_06 |