4-(3-(4-Piperidyl)propyl)piperidine-1-ethanol → HCID 69518912, compound

HRID 1831402Notes

Reaction equation

HRID 1831402 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][CH2:8][CH2:9][CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][OH:18])[CH2:12][CH2:11]2)[CH2:3][CH2:2]1.Cl[C:20]([O:22][C:23]1[CH:28]=[CH:27][C:26]([O:29][C:30]2[CH:35]=[CH:34][C:33]([C:36]([F:39])([F:38])[F:37])=[CH:32][N:31]=2)=[CH:25][CH:24]=1)=[O:21]>>[F:38][C:36]([F:37])([F:39])[C:33]1[CH:34]=[CH:35][C:30]([O:29][C:26]2[CH:27]=[CH:28][C:23]([O:22][C:20]([N:1]3[CH2:6][CH2:5][CH:4]([CH2:7][CH2:8][CH2:9][CH:10]4[CH2:11][CH2:12][N:13]([CH2:16][CH2:17][OH:18])[CH2:14][CH2:15]4)[CH2:3][CH2:2]3)=[O:21])=[CH:24][CH:25]=2)=[N:31][CH:32]=1

Participants

3

Reactant 2

HCID 846044-(3-(4-Piperidyl)propyl)piperidine-1-ethanolHCID 220477624-(5-Trifluoromethylpyridin-2-yloxy)-phenyl chloroformate

Product 1

HCID 69518912HCID 69518912, compound

Procedure

The title product was prepared from 2-[4-(3-piperidin-4-yl-propyl)-piperidin-1-yl]-ethanol and 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate. The reaction mixture was evaporated, diethyl ether (30 ml) was added and the title product isolated by filtration, washed with diethyl ether and ried to give (67%, white solid. HPLC-MS m/z=(M+1) 536.2, Rt: 3.39 min.

Workup

  1. customThe reaction mixture was evaporated
  2. additiondiethyl ether (30 ml) was added

Sources & evidence

ORD record
ord-9907c67744f44f13847daadf3d004bcc
Source dataset
uspto-grants-2006_06
Patent number
US07067517B2

Reaction notes

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