4-(Trifluoromethyl)phenylboronic acid → Methyl-phenyl-carbamic Acid 4'-trifluoromethyl-biphenyl-4-yl Ester

HRID 1831404Notes

Reaction equation

HRID 1831404 reaction equation
I[C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9](=[O:18])[N:10]([CH3:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:4][CH:3]=1.[F:19][C:20]([F:31])([F:30])[C:21]1[CH:26]=[CH:25][C:24](B(O)O)=[CH:23][CH:22]=1>>[F:19][C:20]([F:31])([F:30])[C:21]1[CH:26]=[CH:25][C:24]([C:2]2[CH:7]=[CH:6][C:5]([O:8][C:9](=[O:18])[N:10]([CH3:17])[C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[CH:4][CH:3]=2)=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 27343894-(Trifluoromethyl)phenylboronic acidHCID 69517304Methyl-phenyl-carbamic Acid 4-iodo-phenyl Ester

Product 1

HCID 69519615Methyl-phenyl-carbamic Acid 4'-trifluoromethyl-biphenyl-4-yl Ester

Procedure

The title compound was prepared from methyl-phenyl-carbamic acid 4-iodo-phenyl ester and 4-trifluoromethylphenylboronic acid. The crude product was purified by flash chromatography (Quad flash 12, EtOAc-heptane 1:9) (42%, light brown crystals).

Workup

  1. customThe crude product was purified by flash chromatography (Quad flash 12, EtOAc-heptane 1:9) (42%, light brown crystals)

Sources & evidence

ORD record
ord-38f0d165f49a436b9273659316eda123
Source dataset
uspto-grants-2006_06
Patent number
US07067517B2

Reaction notes

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