Acetaldehyde → HCID 69518085, compound

HRID 1831419Notes

Reaction equation

[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([S:14]([NH:17][CH2:18][CH2:19][C:20]3[CH:25]=[CH:24][C:23]([O:26][C:27](=[O:36])[N:28]([CH3:35])[C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=4)=[CH:22][CH:21]=3)(=[O:16])=[O:15])=[CH:10][CH:9]=2)[CH2:4][CH2:3]1.[CH:37](=O)[CH3:38].C=O>>[CH3:37][CH:38]1[C:25]2[C:20](=[CH:21][CH:22]=[C:23]([O:26][C:27](=[O:36])[N:28]([CH3:35])[C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=3)[CH:24]=2)[CH2:19][CH2:18][N:17]1[S:14]([C:11]1[CH:10]=[CH:9][C:8]([N:5]2[CH2:4][CH2:3][N:2]([CH3:1])[CH2:7][CH2:6]2)=[CH:13][CH:12]=1)(=[O:16])=[O:15]

Participants

Reactant 3

HCID 177Acetaldehyde

HCID 712Formaldehyde

HCID 69517966HCID 69517966, compound

Product 1

HCID 69518085HCID 69518085, compound

Procedure

The title compound was prepared using methyl-phenyl-carbamic acid 4-{2-[4-(4-methyl-piperazin-1-yl)-benzenesulfonylamino]-ethyl}-phenyl ester as the sulfonamide and acetaldehyde in stead of formaldehyde. The crude product was purified by preparative HPLC (Gilson) (12%, brown oil).

Workup

customThe crude product was purified by preparative HPLC (Gilson) (12%, brown oil)

Sources & evidence

ORD record: ord-b63dfc43eab24f0da028ac5db5783f63
Source dataset: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07067517B2

Reaction notes

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