HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Methyl-phenyl-carbamic Acid 4-(imidazol-1-yloxymethyl)-phenyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 1-hydroxyimidazole Hydrochloride | HCID 10313128 | — |
| Reactant | Methyl-phenyl-carbamic Acid 4-hydroxymethyl-phenyl Ester | HCID 69518671 | — |
| Product | Methyl-phenyl-carbamic Acid 4-(imidazol-1-yloxymethyl)-phenyl Ester | HCID 69519595 | 87% |
Reaction Steps
The title compound was prepared as its TFA salt in 87% yield as a solid using methyl-phenyl-carbamic acid 4-hydroxymethyl-phenyl ester and 1-hydroxyimidazole, hydrochloride. 1H NMR (400 MHz; CDCl3): δ 3.42 (br s, 3H), 5.21 (s, 2H), 6.95 (s, 1H), 7.16–7.45 (m, 10H) 8.28 (br s, 1H); HPLC-MS: m/z=324.1 (M+1); Rt=1.92 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07067517B2 |
| Source dataset | uspto-grants-2006_06 |
| ORD ID | ord-ce03c18783d844a8b3baa02d0d7943a3 |
| Source note | uspto-grants-2006_06 |