alpha-Bromo-o-fluorotoluene → HCID 71625272, compound

Participants

Reaction Steps

The product from step (a) (20 mg, 67 μmol) was suspended in dimethyl sulphoxide (450 μL) and Hunig's base (13 μL, 74 μmol) was added. 2-Fluorobenzyl bromide (8.0 μL, 67 μmol) was quickly added to the stirred solution. The reaction was stirred for 60 minutes to give a homogeneous solution The crude solution was diluted to 1 mL with acetonitrile and chromatographed on a reverse phase column using a gradient (40–70% acetonitrile) to give the title compound as a white solid (17 mg, 61% yield).

Provenance & Evidence