2-Benzyloxy-4-(2-chloro-4-methoxy-phenyl)-3-nitro-pyridine → 4-(2-chloro-4-methoxy-phenyl)-3-nitro-1H-pyridin-2-one

Participants

Reaction Steps

2-Benzyloxy-4-(2-chloro-4-methoxy-phenyl)-3-nitro-pyridine (1.51 g, 4.07 mmol) was dissolved in TFA (20 mL) and stirred at room temperature for 4 h. The reaction mixture was concentrated, washed with toluene, and concentrated in vacuo to yield 1.19 g (100%) of 4-(2-chloro-4-methoxy-phenyl)-3-nitro-1H-pyridin-2-one as a solid: MS (AP) m/z 280.7 [(M+H)+, 100].

Provenance & Evidence