Sodium Dithionite → 4-(2-chloro-4-methoxy-phenyl)-N2-(1-cyclopropyl-propyl)-pyridine-2,3-diamine

Participants

Role	Name	HCID	Charge
Reactant	Sodium Dithionite	HCID 24489	—
Reactant	[4-(2-Chloro-4-methoxy-phenyl)-3-nitro-pyridin-2-yl]-(1-cyclopropyl-propyl)-amine	HCID 22052203	—
Product	4-(2-chloro-4-methoxy-phenyl)-N2-(1-cyclopropyl-propyl)-pyridine-2,3-diamine	HCID 69657985	96%

Reaction Steps

[4-(2-Chloro-4-methoxy-phenyl)-3-nitro-pyridin-2-yl]-(1-cyclopropyl-propyl)-amine (0.56 g, 1.55 mmol) and Na2S2O4 (2.17 g, 12.5 mmol) were treated substantially as described in Part E of Example 9 to give 0.49 g (96%) of crude 4-(2-chloro-4-methoxy-phenyl)-N2-(1-cyclopropyl-propyl)-pyridine-2,3-diamine: MS (AP) m/z 331.8 [(M+H)+, 100].

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07067658B2
Source dataset	uspto-grants-2006_06
ORD ID	ord-6a615b688056484180cd948b22dc84f3
Source note	uspto-grants-2006_06