Sodium Dithionite → 4-(2-chloro-4-methoxy-phenyl)-N2-(2-methoxy-1-methyl-ethyl)-pyridine-2,3-diamine

Participants

Role	Name	HCID	Charge
Reactant	Sodium Dithionite	HCID 24489	—
Reactant	[4-(2-Chloro-4-methoxy-phenyl)-3-nitro-pyridin-2-yl]-(2-methoxy-1-methyl-ethyl)-amine	HCID 22052173	—
Product	4-(2-chloro-4-methoxy-phenyl)-N2-(2-methoxy-1-methyl-ethyl)-pyridine-2,3-diamine	HCID 69658148	85.5%

Reaction Steps

[4-(2-chloro-4-methoxy-phenyl)-3-nitro-pyridin-2-yl]-(2-methoxy-1-methyl-ethyl)-amine (0.28 g, 0.80 mmol) and Na2S2O4 (1.12 g, 6.42 mmol) were treated substantially as described in Part E of Example 9 to give 0.22 g (84%) 4-(2-chloro-4-methoxy-phenyl)-N2-(2-methoxy-1-methyl-ethyl)-pyridine-2,3-diamine: MS (AP) m/z 321.8 [(M+H)+, 72].

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07067658B2
Source dataset	uspto-grants-2006_06
ORD ID	ord-b542bc15f7914dae86056b0ac6fba0fc
Source note	uspto-grants-2006_06