Sodium Sulfate → HCID 86591988, compound

HRID 1831537Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][N:12]=[C:11]([NH2:15])[C:10]=2[N+:16]([O-])=O)=[C:5]([CH3:19])[CH:4]=1.[O-]S([O-])(=O)=O.[Na+].[Na+]>>[CH3:1][O:2][CH2:3][CH:4]([NH:15][C:11]1[C:10]([NH2:16])=[C:9]([C:6]2[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][C:5]=2[CH3:19])[CH:14]=[CH:13][N:12]=1)[CH3:5]

Participants

Reactant 2

HCID 24436Sodium Sulfate

HCID 86591989HCID 86591989, compound

Product 1

HCID 86591988HCID 86591988, compoundYield 61%

Procedure

2-Methoxy-1-methyl-ethyl)-[4-(4-methoxy-2-methyl-phenyl)-3-nitro-pyridin-2-yl]amine (0.120 g, 0.36 mmol), and Na2SO4 (0.509 g, 2.9 mmol), were treated as in Part D of Example 67a to give a crude yield of 0.066 g (61%) of N2-(2-methoxy-1-methyl-ethyl)-4-(4-methoxy-2-methyl-phenyl)-pyridine-2,3-diamine; MS(AP) m/z 302.2 [(M+H)+, 100]. The crude product was taken on to Part E.

Sources & evidence

ORD record: ord-3657fbdeea5648f78677f2704c8ec6f0
Source dataset: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07067658B2

Reaction notes

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