Methyl pyruvate → HCID 22052052, compound

Participants

Reaction Steps

N2-(2-Methoxy-1-methyl-ethyl)-4-(4-methoxy-2-methyl-phenyl)-pyridine-2,3-diamine (0.066 g, 0.22 mmol) and methyl pyruvate (79 μL, 0.88 mmol) were treated substantially as in Part E of Example 67a to give 4-(2-methoxy-1-methyl-ethyl)-8-(4-methoxy-2-methyl-phenyl)-2-methyl-4H-pyrido[2,3-b]pyrazin-3-one (Example 73a): 1H NMR (300 MHz, CDCl3): δ 8.49–8.47 (d, 1H, J=4.8 Hz), 7.16–7.12 (m, 2H), 6.86–6.82 (m, 2H), 4.41–4.36 (m, 1H), 3.87 (s, 3H), 3.84–3.80 (m, 2H), 3.34 (s, 3H), 2.48 (s, 3H), 2.12 (s, 3H), 1.62–1.60 (d, 3H, J=6.9 Hz). MS (AP) 354.2 [(M+H)+, 100].

Provenance & Evidence