HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Dithionite → (R)-4-(5-Fluoro-4-methoxy-2-methyl-phenyl)-N2-(1-methoxymethyl-propyl)-pyridine-2,3-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Dithionite | HCID 24489 | — |
| Reactant | (R)-[4-(5-fluoro-4-methoxy-2-methyl-phenyl)-3-nitro-pyridin-2-yl]-(1-methoxymethyl-propyl)-amine | HCID 69658289 | — |
| Product | (R)-4-(5-Fluoro-4-methoxy-2-methyl-phenyl)-N2-(1-methoxymethyl-propyl)-pyridine-2,3-diamine | HCID 69658079 | 102.3% |
Reaction Steps
(R)-[4-(5-fluoro-4-methoxy-2-methyl-phenyl)-3-nitro-pyridin-2-yl]-(1-methoxymethyl-propyl)-amine (0.16 g, 0.44 mmol) and Na2S2O4 (1.15 g, 6.6 mmol) were treated as in Part E of Example 9 to give 0.15 g (98%) crude (R)-4-(5-Fluoro-4-methoxy-2-methyl-phenyl)-N2-(1-methoxymethyl-propyl)-pyridine-2,3-diamine. MS (AP) m/z 334.3 [(M+H)+, 100].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07067658B2 |
| Source dataset | uspto-grants-2006_06 |
| ORD ID | ord-01a7afc6bec74733be00a6ca3555e99b |
| Source note | uspto-grants-2006_06 |