Methyl pyruvate → HCID 22052075, compound

Participants

Reaction Steps

4-(2-chloro-4-difluoromethoxy-phenyl)-N2-(1-cyclopropyl-propyl)-pyridine-2,3-diamine (0.088 g, 0.24 mmol) and methyl pyruvate (140 μL, 1.54 mmol) were treated as in Part F of Example 113 with the exception that ethanol was used as the solvent, gave 8-(2-Chloro-4-difluoromethoxy-phenyl)-4-(1-cyclopropyl-propyl)2-methyl-4H-pyrido[2,3-b]pyrazin-3-one (Example 115a): 1H NMR (300 MHz, CDCl3) δ 8.48–8.46 (2d, 1H, J=4.7 Hz), 7.37–7.33 (m, 2H), 7.19–7.14 (m, 2H), 6.86–6.37 (t,1H, J=73.3 Hz), 5.16–4.92, 4.90–4.41 (2m, 1H), 2.57 (s, 3H), 2.49–2.38 (m, 1H), 2.29–2.19 (m, 1H), 2.10–1.93 (m, 1H), 0.90–0.85 (t, 3H, J=7.3), 0.80–0.71 (m, 1H), 0.59–0.50 (m, 1H), 0.49–0.48 (m, 1H), 0.23–0.18 (m, 1H). MS (AP) m/z 420.1 [(M+H)+, 100].

Provenance & Evidence