HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-(2-chloro-4-difluoromethoxy-phenyl)3-nitro-3H-pyridin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 2-Benzyloxy-4-(2-chloro-4-difluoromethoxy-phenyl)-3-nitro-pyridine | HCID 22052047 | — |
| Product | 4-(2-chloro-4-difluoromethoxy-phenyl)3-nitro-3H-pyridin-2-one | HCID 22052138 | 93% |
Reaction Steps
2-Benzyloxy-4-(2-chloro-4-difluoromethoxy-phenyl)-3-nitro-pyridine (5.40 g, 13.3 mmol) and TFA (25 mL) were treated as in Part B of Example 113 with the exception that the crude product was isolated as 3.90 g (93%) of 4-(2-chloro-4-difluoromethoxy-phenyl)-3-nitro-3H-pyridin-2-one: MS(AP) m/z 317.0 [(M+H)+, 90], 357.9 [(M+H+CH3CN)+, 100].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07067658B2 |
| Source dataset | uspto-grants-2006_06 |
| ORD ID | ord-c399f60adceb455e97b58e1e61cb5bbe |
| Source note | uspto-grants-2006_06 |