Methyl pyruvate → HCID 22052200, compound

Participants

Reaction Steps

4-(2-Chloro-4-difluoromethoxy-phenyl)-N2-(1-methoxymethyl-propyl)-pyridine-2,3-diamine (0.268 g, 0.72 mmol) and methyl pyruvate (130 μL, 1.44 mmol) were treated substantially as described in Part F of Example 113 to give 8-(2-chloro-4-difluoromethoxy-phenyl)-4-(1-methoxymethyl-propyl)-2-methyl-4H-pyrido[2,3-b]pyrazin-3-one (Example 122a): 1H NMR (300 MHz, CDCl3) δ □8.54–8.51 (m, 1H), 7.33–7.32 (m,2H), 7.21–7.14 (m, 2H), 6.85–6.37 (t, 1H, J=72.9 Hz), 6.21–6.19, 5.64–5.58 (2m, 1H), 4.40–4.31 (m, 1H), 3.92–3.79 (m, 1H), 3.33 (s, 3H), 2.48 (s, 3H), 2.30–2.20 (m, 1H),2.13–1.96 (m, 1H), 0.90–0.85 (t, 3H, J=7.7 Hz). MS (AP) m/z 424.1 [(M+H)+, 100].

Provenance & Evidence