HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Dithionite → 4-(2-chloro-4-trifluoromethyl-phenyl)-N2-(2-methoxy-1-methyl-ethyl)-pyridine-2,3-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Dithionite | HCID 24489 | — |
| Reactant | [4-(2-Chloro-4-trifluoromethyl-phenyl)-3-nitro-pyridin-2-yl]-(2-methoxy-1-methyl-ethyl)-amine | HCID 22052211 | — |
| Product | 4-(2-chloro-4-trifluoromethyl-phenyl)-N2-(2-methoxy-1-methyl-ethyl)-pyridine-2,3-diamine | HCID 69658285 | 74.9% |
Reaction Steps
[4-(2-Chloro-4-trifluoromethyl-phenyl)-3-nitro-pyridin-2-yl]-(2-methoxy-1-methyl-ethyl)-amine (0.45 g, 1.15 mmol) and Na2S2O4 (1.62 g, 9.32 mmol) were treated substantially as described in Part E of Example 9 to yield 0.31 g (74%) of 4-(2-chloro-4-trifluoromethyl-phenyl)-N2-(2-methoxy-1-methyl-ethyl)-pyridine-2,3-diamine: MS (AP) m/z 359.8 [(M+H)+, 97].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07067658B2 |
| Source dataset | uspto-grants-2006_06 |
| ORD ID | ord-ca93f47611b143d685d361ff65a47c9f |
| Source note | uspto-grants-2006_06 |