Sodium Dithionite → 4-(2-chloro-4-trifluoromethyl-phenyl)-N2-(1-methoxymethyl-propyl)-pyridine-2,3-diamine

Participants

Role	Name	HCID	Charge
Reactant	Sodium Dithionite	HCID 24489	—
Reactant	[4-(2-Chloro-4-trifluoromethyl-phenyl)-3-nitro-pyridin-2-yl]-(1-methoxymethyl-propyl)-amine	HCID 22052174	—
Product	4-(2-chloro-4-trifluoromethyl-phenyl)-N2-(1-methoxymethyl-propyl)-pyridine-2,3-diamine	HCID 69658046	78%

Reaction Steps

[4-(2-Chloro-4-trifluoromethyl-phenyl)-3-nitro-pyridin-2-yl]-(1-methoxymethyl-propyl)-amine (0.40 g, 1.0 mmol) and Na2S2O4 (1.39 g, 8.0 mmol) were treated substantially as described in Part E of Example 9 to yield 0.29 g (78%) of 4-(2-chloro-4-trifluoromethyl-phenyl)-N2-(1-methoxymethyl-propyl)-pyridine-2,3-diamine: MS (AP) m/z 373.8 [(M+H)+, 100].

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07067658B2
Source dataset	uspto-grants-2006_06
ORD ID	ord-b7befaffeb084babb4395e25a5026d54
Source note	uspto-grants-2006_06