2-Butanamine, 1-methoxy- → HCID 22052163, compound

HRID 1831573Notes

Reaction equation

HRID 1831573 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([F:10])=[CH:4][C:3]=1[C:11]1[CH:16]=[CH:15][NH:14][C:13](=O)[C:12]=1[N+:18]([O-:20])=[O:19].FC(F)(F)S(O)(=O)=O.[CH3:29][O:30][CH2:31][CH:32]([NH2:35])[CH2:33][CH3:34]>>[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([F:10])=[CH:4][C:3]=1[C:11]1[CH:16]=[CH:15][N:14]=[C:13]([NH:35][CH:32]([CH2:31][O:30][CH3:29])[CH2:33][CH3:34])[C:12]=1[N+:18]([O-:20])=[O:19]

Participants

3

Reactant 2

HCID 938372-Butanamine, 1-methoxy-HCID 86591995HCID 86591995, compound

Product 1

HCID 22052163HCID 22052163, compoundYield 13%

Procedure

Trifluoro-methanesulfonic acid 4-(2-Chloro-5-fluoro-4-methoxy-phenyl)-3-nitro-1H-pyridin-2-one (0.3 g, 0.70 mmol), prepared substantially as described in Part C of Example 19a, and 1-methoxymethyl-propylamine (0.28 g, 2.79 mmol) were treated substantially as described in Part C of Example 19a to produce 35 mg (13%) of crude [4-(2-chloro-5-fluoro-4-methoxy-phenyl)-3-nitro-pyridin-2-yl]-(1-methoxymethyl-propyl)-amine.

Workup

  1. additionwere treated substantially

Sources & evidence

ORD record
ord-fe11a7d7d2454e188e9899740125fe4e
Source dataset
uspto-grants-2006_06
Patent number
US07067658B2

Reaction notes

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