2-Butanamine, 1-methoxy- → HCID 22052066, compound

HRID 1831580Notes

Reaction equation

HRID 1831580 reaction equation
[Cl:1][C:2]1[C:3]([O:26][CH3:27])=[CH:4][C:5]([CH3:25])=[C:6]([C:8]2[CH:13]=[CH:12][N:11]=[C:10](OS(C(F)(F)F)(=O)=O)[C:9]=2[N+:22]([O-:24])=[O:23])[CH:7]=1.[CH3:28][O:29][CH2:30][CH:31]([NH2:34])[CH2:32][CH3:33]>>[Cl:1][C:2]1[C:3]([O:26][CH3:27])=[CH:4][C:5]([CH3:25])=[C:6]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([NH:34][CH:31]([CH2:30][O:29][CH3:28])[CH2:32][CH3:33])[C:9]=2[N+:22]([O-:24])=[O:23])[CH:7]=1

Participants

3

Reactant 2

HCID 938372-Butanamine, 1-methoxy-HCID 86591996HCID 86591996, compound

Product 1

HCID 22052066HCID 22052066, compoundYield 40%

Procedure

Trifluoro-methanesulfonic acid 4-(5-chloro-4-methoxy-2-methyl-phenyl)-3-nitro-pyridin-2-yl ester (0.38 g, 0.89 mmol) and 1-methoxymethyl-propylamine (0.23 g, 2.23 mmol) were treated substantially as described in Part C of Example 19a to produce 0.13 g (40%) of crude [4-(5-chloro-4-methoxy-2-methyl-phenyl)-3-nitro-pyridin-2-yl]-(1-methoxymethyl-propyl)-amine: MS (EI) m/z 380.19 [(M+H)+, 100].

Sources & evidence

ORD record
ord-058670083cd0404ea6b83a492a5a7efa
Source dataset
uspto-grants-2006_06
Patent number
US07067658B2

Reaction notes

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