Stannous Chloride → 4-(2-chloro-4-methoxy-5-methyl-phenyl)-N2-(1-cyclopropyl-propyl)-pyridine-2,3-diamine

Participants

Role	Name	HCID	Charge
Reactant	Stannous Chloride	HCID 24479	—
Reactant	[4-(2-Chloro-4-methoxy-5-methyl-phenyl)-3-nitro-pyridin-2-yl]-(1-cyclopropyl-propyl)-amine	HCID 22052097	—
Product	4-(2-chloro-4-methoxy-5-methyl-phenyl)-N2-(1-cyclopropyl-propyl)-pyridine-2,3-diamine	HCID 69658136	98%

Reaction Steps

[4-(2-Chloro-4-methoxy-5-methyl-phenyl)-3-nitro-pyridin-2-yl]-(1-cyclopropyl-propyl)-amine (90 mg, 0.24 mmol) and SnCl2 (0.13 g, 0.72 mmol) were treated substantially as described in Part D of Example 74a to yield 80 mg (98%) of 4-(2-chloro-4-methoxy-5-methyl-phenyl)-N2-(1-cyclopropyl-propyl)-pyridine-2,3-diamine: MS (EI) m/z 346.22 [(M+H)+, 100].

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07067658B2
Source dataset	uspto-grants-2006_06
ORD ID	ord-ba678e07a1014be3bb83b24619517c5d
Source note	uspto-grants-2006_06