HuagongsheHuagongshe Chemistry Print Report · For research reference only
[4-(2-Chloro-4-dimethylamino-5-fluoro-phenyl)-3-nitro-pyridin-2-yl]-(1-cyclopropyl-propyl)-amine → 4-(2-chloro-4-dimethylamino-5-fluoro-phenyl)-N2-(1-cyclopropyl-propyl)-pyridine-2,3-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [4-(2-Chloro-4-dimethylamino-5-fluoro-phenyl)-3-nitro-pyridin-2-yl]-(1-cyclopropyl-propyl)-amine | HCID 22052078 | — |
| Reactant | Tin dichloride dihydrate | HCID 43835034 | — |
| Product | 4-(2-chloro-4-dimethylamino-5-fluoro-phenyl)-N2-(1-cyclopropyl-propyl)-pyridine-2,3-diamine | HCID 69657948 | 100.1% |
Reaction Steps
[4-(2-Chloro-4-dimethylamino-5-fluoro-phenyl)-3-nitro-pyridin-2-yl]-(1-cyclopropyl-propyl)-amine (300 mg, 0.76 mmol) and SnCl2.H2O (1.2 g, 6.1 mmol) were treated substantially as described in Part D of Example 74a to yield 276 mg of crude 4-(2-chloro-4-dimethylamino-5-fluoro-phenyl)-N2-(1-cyclopropyl-propyl)-pyridine-2,3-diamine: MS (EI) m/z 363.24 [(M+H)+, 100].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07067658B2 |
| Source dataset | uspto-grants-2006_06 |
| ORD ID | ord-01ba4f9e374e4d56b359432109e06383 |
| Source note | uspto-grants-2006_06 |