Tin dichloride dihydrate → (R)-4-(2-chloro-4-dimethylamino-5-fluoro-phenyl)-N2-(1-cyclopropyl-ethyl)-pyridine-2,3-diamine

Participants

Role	Name	HCID	Charge
Reactant	Tin dichloride dihydrate	HCID 43835034	—
Reactant	(R)-[4-(2-Chloro-4-dimethylamino-5-fluoro-phenyl)-3-nitro-pyridin-2-yl]-(1-cyclopropyl-ethyl)-amine	HCID 69658051	—
Product	(R)-4-(2-chloro-4-dimethylamino-5-fluoro-phenyl)-N2-(1-cyclopropyl-ethyl)-pyridine-2,3-diamine	HCID 69658225	95.3%

Reaction Steps

(R)-[4-(2-Chloro-4-dimethylamino-5-fluoro-phenyl)-3-nitro-pyridin-2-yl]-(1-cyclopropyl-ethyl)-amine (314 mg, 0.83 mmol) and SnCl2.H2O (472 mg, 2.5 mmol) were treated substantially as described in Part D of Example 74a to yield 276 mg of crude (R)-4-(2-chloro-4-dimethylamino-5-fluoro-phenyl)-N2-(1-cyclopropyl-ethyl)-pyridine-2,3-diamine: MS (EI) m/z 349.24 [(M+H)+, 100].

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07067658B2
Source dataset	uspto-grants-2006_06
ORD ID	ord-c2aec4ceb16e4b89b9f3a7cda1f3b640
Source note	uspto-grants-2006_06