2-Butanamine, 1-methoxy- → HCID 22052227, compound

HRID 1831593Notes

Reaction equation

HRID 1831593 reaction equation
OC(C(F)(F)F)=O.[Cl:8][C:9]1[CH:14]=[C:13]([N:15]([CH3:17])[CH3:16])[C:12]([F:18])=[CH:11][C:10]=1[C:19]1[CH:24]=[CH:23][N:22]=[C:21](OS(C(F)(F)F)(=O)=O)[C:20]=1[N+:33]([O-:35])=[O:34].[CH3:36][O:37][CH2:38][CH:39]([NH2:42])[CH2:40][CH3:41]>>[Cl:8][C:9]1[CH:14]=[C:13]([N:15]([CH3:17])[CH3:16])[C:12]([F:18])=[CH:11][C:10]=1[C:19]1[CH:24]=[CH:23][N:22]=[C:21]([NH:42][CH:39]([CH2:38][O:37][CH3:36])[CH2:40][CH3:41])[C:20]=1[N+:33]([O-:35])=[O:34]

Participants

3

Reactant 2

HCID 938372-Butanamine, 1-methoxy-HCID 131725817Trifluoro-methanesulfonic acid 4-(2-chloro-4-dimethylamino-5-fluoro-phenyl)-3-nitro-pyridin-2-yl ester TFA

Product 1

HCID 22052227HCID 22052227, compoundYield 81.3%

Procedure

Trifluoro-methanesulfonic acid 4-(2-chloro-4-dimethylamino-5-fluoro-phenyl)-3-nitro-pyridin-2-yl ester TFA (39.6 mg, 0.093 mmol), prepared substantially as described in Part C of Example 19a, and 1-methoxymethyl-propylamine (191.0 mg, 1.85 mmol) were treated substantially as described in Part C of Example 19a to produce 30 mg (81%) of crude [4-(2-chloro-4-dimethylamino-5-fluoro-phenyl)-3-nitro-pyridin-2-yl]-(1-methoxymethyl-propyl)-amine: MS (EI) m/z 397.19 [(M+H)+, 100].

Workup

  1. additionwere treated substantially

Sources & evidence

ORD record
ord-d61f0b2cc0eb4ed48bbbce7a566038eb
Source dataset
uspto-grants-2006_06
Patent number
US07067658B2

Reaction notes

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