4-Ethoxyaniline → HCID 22052282, compound

HRID 1831610Notes

Reaction equation

HRID 1831610 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][N:8]([C:29](=[O:41])[CH2:30][C:31]2[CH:36]=[CH:35][C:34]([C:37]([F:40])([F:39])[F:38])=[CH:33][CH:32]=2)[CH:9]([C:11]2[N:20]([C:21]3[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=3)[C:19](=[O:28])[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[N:12]=2)[CH3:10])[CH:2]=1.CCOC1C=CC(N)=CC=1.Cl.N1C=CC=CC=1C[Cl:60]>>[ClH:60].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][N:8]([C:29](=[O:41])[CH2:30][C:31]2[CH:32]=[CH:33][C:34]([C:37]([F:40])([F:39])[F:38])=[CH:35][CH:36]=2)[CH:9]([C:11]2[N:20]([C:21]3[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=3)[C:19](=[O:28])[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[N:12]=2)[CH3:10])[CH:2]=1

Participants

4

Reactant 3

HCID 90764-EthoxyanilineHCID 23392Picolyl chloride hydrochlorideHCID 22052244HCID 22052244, compound

Product 1

HCID 22052282HCID 22052282, compound

Procedure

The synthesis of compound 3.04 followed the method described for compound 3.02. p-Phenetidine was used in place of 4-fluoroaniline in step 1 of the synthetic sequence. 2-Picolylchloride hydrochloride was used in place of 3-picolylchloride hydrochloride in step 3 of the synthetic sequence. Characterization of the products follows.

Sources & evidence

ORD record
ord-2a3469dd9237415aa6f83f60d002661e
Source dataset
uspto-grants-2006_06
Patent number
US07067662B2

Reaction notes

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