Acetic Acid → HCID 15429323, compound

Participants

Reaction Steps

A solution of 1.32 g (5.3 mmol) of 7-(2-furanyl)-1,2,3,5-tetrahydrocyclo-penta[c]quinolin-4-one in 300 ml of methanol is mixed with 2.58 g (10.6 mmol) of magnesium and 0.06 ml of acetic acid. After 15 hours at room temperature, another 1.29 g (5.3 mmol) of magnesium is added to it. The batch is stirred for 15 hours at room temperature, treated with 10% hydrochloric acid (500 ml) and extracted with ethyl acetate (3×300 ml). The combined extracts are dried (Na2SO4) and concentrated by evaporation in a vacuum. Column chromatography on silica gel with hexane-ethyl acetate yields 0.49 g of product.

Provenance & Evidence