Lawesson's reagent → HCID 11385549, compound

Participants

Reaction Steps

A solution of 75 mg (0.17 mmol) of 7-(N-tert-butoxycarbonyl-3-chlorobenzyl-amino)methyl-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinolin-4-one in 5 ml of 1,2-dimethoxyethane is mixed with 138 mg (0.34 mmol) of Lawesson's reagent. After 1.5 hours at room temperature, the batch is refluxed for 0.75 hour and then concentrated by evaporation in a vacuum. Column chromatography on silica gel with hexane-ethyl acetate yields 65 mg of product.

Provenance & Evidence