Acetic Anhydride → HCID 69652815, compound

HRID 1831745Notes

Reaction equation

HRID 1831745 reaction equation
[OH:1][CH2:2][CH2:3][C:4]1[CH:5]=[CH:6][C:7]2[CH:8]3[CH2:17][CH2:16][CH2:15][CH:9]3[C:10](=[O:14])[NH:11][C:12]=2[CH:13]=1.[C:18](OC(=O)C)(=[O:20])[CH3:19]>N1C=CC=CC=1>[C:18]([O:1][CH2:2][CH2:3][C:4]1[CH:5]=[CH:6][C:7]2[CH:8]3[CH2:17][CH2:16][CH2:15][CH:9]3[C:10](=[O:14])[NH:11][C:12]=2[CH:13]=1)(=[O:20])[CH3:19]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 18516364HCID 18516364, compound

Product 1

HCID 69652815HCID 69652815, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A solution of 560 mg (2.4 mmol) of 7-hydroxyethyl-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinolin-4-one in 10 ml of pyridine is stirred with 5 ml of acetic anhydride for 24 hours at room temperature. The batch is concentrated by evaporation in a vacuum and purified by column chromatography on silica gel with hexane-ethyl acetate: 500 mg of product.

Workup

  1. concentrationThe batch is concentrated by evaporation in a vacuum
  2. custompurified by column chromatography on silica gel with hexane-ethyl acetate

Sources & evidence

ORD record
ord-e3c77cc5f4314de6a8383804307f3484
Source dataset
uspto-grants-2006_06
Patent number
US07067667B2

Reaction notes

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