Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-Bromo-3-hydroxybenzoic acid | HCID 6420973 | — |
| Product | Methyl 4-Bromo-3-hydroxybenzoate | HCID 6425184 | — |
Reaction Steps
1.5 ml of thionyl chloride was added to 40 ml of MeOH at 0° C. The solution was stirred for 10 min and 5 g of 4-Bromo-3-hydroxy-benzoic acid was added. The reaction was stirred for 16 h at RT then heated to 50° C. for 3 h. The solvents were removed under reduced pressure. The residue was used directly in the next step. Yield 5.92 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07067665B2 |
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| Source dataset | uspto-grants-2006_06 |
|---|
| ORD ID | ord-df456d264d414427ac24021d0c47b33b |
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| Source note | uspto-grants-2006_06 |
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