Ethyl Acetate → tert-butyl N-[(1-cyanopiperidin-4-yl)methyl]carbamate

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Reaction Steps

Piperidin-4-ylmethyl-carbamic acid tert-butyl ester (4 g, 18.66 mmol) was suspended in 120 ml of acetonitrile. Dried potassium carbonate (2.837 g, 20.53 mmol) was added. A solution of bromoacetonitrile in (3.72 ml, 5 mmolar solution, 18.66 mmol) was added (argon atmosphere) and the mixture was stirred for 3 hours. After addition of aqueous FeSO4 solution and ethyl acetate, the separated solid was filtered and the organic layer separated, dried and evaporated.

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