Triethylamine → tert-butyl N-[[1-[(E)-N'-hydroxycarbamimidoyl]piperidin-4-yl]methyl]carbamate

Participants

Reaction Steps

(1-Cyano-piperidin-4-ylmethyl)-carbamic acid tert-butyl ester (2 g, 8.36 mmol), hydroxylamine hydrochloride (3.48 g, 50.14 mmol) and triethylamine (5.92 g, 58.5 mmol) were stirred in 30 ml of isopropanol at room temperature for 4 hours. The mixture was evaporated. After addition of water (pH4) and ethyl acetate, the organic layer was separated and evaporated.

Provenance & Evidence