反应详情

In a Fischer-Porter bottle, added a solution of 4-(benzyloxy)-1-(3-fluorobenzyl)pyridin-2(1H)-one (4.5 g, 14.56 mmol) in absolute ethanol-(20 mL). Flushed the solution with nitrogen then added palladium catalyst (1.05 g). Sealed bottle and evacuated system. The system was purged with hydrogen gas (2×15 psi) to check for leaks. The reaction was charged with hydrogen (35 psi) and stirred at room temperature for 45 min. The system was evacuated and flushed with nitrogen. The reaction was filtered and the catalyst was carefully washed with fresh ethanol. The filtrate was concentrated under reduced pressure.

1. customFlushed the solution with nitrogen
2. customSealed bottle
3. customevacuated system
4. customThe system was purged with hydrogen gas (2×15 psi)
5. additionThe reaction was charged with hydrogen (35 psi)
6. customThe system was evacuated
7. customflushed with nitrogen
8. filtrationThe reaction was filtered
9. washthe catalyst was carefully washed with fresh ethanol
10. concentrationThe filtrate was concentrated under reduced pressure