HCID 54724162, compound → HCID 22050728, compound

HRID 1831904Notes

Reaction equation

HRID 1831904 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[CH2:5][N:6]1[CH:11]=[CH:10][C:9](O)=[CH:8][C:7]1=[O:13]>C(N)C1C=CC=CC=1>[CH2:5]([NH:6][C:9]1[CH:10]=[CH:11][N:6]([CH2:5][C:4]2[CH:14]=[CH:15][CH:16]=[C:2]([F:1])[CH:3]=2)[C:7](=[O:13])[CH:8]=1)[C:4]1[CH:14]=[CH:15][CH:16]=[CH:2][CH:3]=1

Participants

3

Reactant 1

HCID 54724162HCID 54724162, compound

Product 1

HCID 22050728HCID 22050728, compound

Reagents, catalysts & solvents 1

HCID 7504BenzylamineSolvent

Procedure

Heated a reaction mixture of 1-(3-fluorobenzyl)-4-hydroxypyridin-2(1H)-one (1.005 g, 4.5 mmol) in benzylamine (15 mL) at reflux (1850 C) under nitrogen atmosphere for 24 h. The reaction was monitored by ES-MS (MH+ 309). The solvent was removed by vacuum distillation to give a yellow residue.

Workup

  1. temperatureHeated
  2. temperatureat reflux (1850 C) under nitrogen atmosphere for 24 h
  3. customThe solvent was removed by vacuum distillation
  4. customto give a yellow residue

Sources & evidence

ORD record
ord-f1ef2509faa946738ccd34054eb5e675
Source dataset
uspto-grants-2006_06
Patent number
US07067540B2

Reaction notes

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