HCID 22050501, compound → HCID 22050766, compound

Participants

Reaction Steps

Ion exchange (12.5 g) BioRad AG 2×8 resin (200-400 mesh chloride form) was washed with 1M HCl (150 mL), and equilibrated for 2.5 h. This resin was loaded onto a column, and added a solution of EXAMPLE 387 (1.2 g, 2.4 mmol) in water/CH3CN (1:1). The column was eluted slowly over 1 h, fractions were collected, and freeze dried to afford the desired HCl salt (1.03 g, 97%) as a white solid: 1H NMR (CD3OD, 400 Hz) δ 7.60 (m, 2H), 7.04 (m, 2H), 6.64 (s, 1H), 5.31 (s, 2H), 5.17 (s, 2H), 2.50 (s, 3H), 2.47 (s, 3H); ES-HRMS m/z 407.1079 (M+H C19H17N4O2ClF2 requires 407.1081).

Provenance & Evidence