Methyl 3-Amino-4-chlorobenzoate → HCID 54724168, compound

HRID 1832048Notes

Reaction equation

HRID 1832048 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[Cl:12])[C:5]([O:7][CH3:8])=[O:6].[OH:13][C:14]1[CH:19]=[C:18]([CH3:20])[O:17][C:16](=O)[CH:15]=1>>[Cl:12][C:11]1[CH:10]=[CH:9][C:4]([C:5]([O:7][CH3:8])=[O:6])=[CH:3][C:2]=1[N:1]1[C:18]([CH3:20])=[CH:19][C:14]([OH:13])=[CH:15][C:16]1=[O:17]

Participants

3

Reactant 2

HCID 593055Methyl 3-Amino-4-chlorobenzoateHCID 546757574-Hydroxy-6-methyl-2-pyrone

Product 1

HCID 54724168HCID 54724168, compound

Procedure

A condensation reaction with methyl 3-amino-4-chlorobenzoate (14.5 g, 78.2 mmol) and 4-hydroxy-6-methyl pyranone under reaction condition similar to the one described in Example 465—step 3 gave 12.32 (53.8%) of desired product. Step 3—Preparation of methyl-4-chloro-3-[4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-oxopyridin-1(2H)-yl]benzoate.

Workup

  1. customunder reaction condition similar to the one

Sources & evidence

ORD record
ord-abf4ed423d3a44659ca50627ce535af4
Source dataset
uspto-grants-2006_06
Patent number
US07067540B2

Reaction notes

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