反应详情

NBS (0.69 g, 3.85 mmol) was added to a solution of 3-[4-[(4-fluoro-2-{[(methoxycarbonyl)amino]methyl}benzyl)oxy]-6-methyl-2-oxopyridin-1(2H)-yl]-4-methylbenzoic acid (from Step 4) (1.75 g, 3.85 mmol) in DCM (45 mL). After 1.5 h, solvent removed on rotary evaporator. Solid dissolved in EtOAc and hexane added, resulting in a solid precipitate. Solid filtered. Solid subsequently dissolved in DCM and washed with water. Organic layer dried over Na2SO4, filtered, and concentrated. Pale yellow solid dried in vacuo (1.47 g, 72%).

1. customsolvent removed on rotary evaporator
2. dissolutionSolid dissolved in EtOAc
3. additionhexane added
4. customresulting in a solid precipitate
5. filtrationSolid filtered
6. dissolutionSolid subsequently dissolved in DCM
7. washwashed with water
8. dry with materialOrganic layer dried over Na2SO4
9. filtrationfiltered
10. concentrationconcentrated
11. customPale yellow solid dried in vacuo (1.47 g, 72%)