Sodium Iodide → N-[3-(1-{5-[4-(3,4-Difluorophenyl)-2-oxo-1,3-oxazolidin-3-YL]pentyl}-4-piperidinyl)phenyl]-2-methylpropanamide

HRID 1832233Notes

Reaction equation

Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][N:7]1[CH:11]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[C:14]([F:19])[CH:13]=2)[CH2:10][O:9][C:8]1=[O:20].[CH3:21][CH:22]([CH3:38])[C:23]([NH:25][C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([CH:32]2[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]2)[CH:27]=1)=[O:24].[Na+].[I-].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[F:19][C:14]1[CH:13]=[C:12]([CH:11]2[CH2:10][O:9][C:8](=[O:20])[N:7]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][N:35]2[CH2:36][CH2:37][CH:32]([C:28]3[CH:27]=[C:26]([NH:25][C:23](=[O:24])[CH:22]([CH3:21])[CH3:38])[CH:31]=[CH:30][CH:29]=3)[CH2:33][CH2:34]2)[CH:17]=[CH:16][C:15]=1[F:18]

Participants

Conditions

Temperature: 50 °C

Procedure

A mixture of 3-(5-bromopentyl)-4-(3,4-difluorophenyl)-1,3-oxazolidin-2-one (38.0 mg, 0.110 mmol), 2-methyl-N-[3-(4-piperidinyl)phenyl]propanamide (26.0 mg, 0.100 mmol), NaI (23.0 mg, 0.150 mmol), and K2CO3 (14.0 mg, 0.100 mmol) in DMF (2 mL) was heated for 1 h at 50° C. The crude product was purified by preparative TLC using CH2Cl2/MeOH/isopropyl amine (19:1:0.2) to give the desired product (21 mg, 41%). 1H NMR (400 MHz, CDCl3) δ 7.49 (s, 1H), 7.39–7.32 (m, 2H), 7.26–7.20 (m, 2H), 7.18–7.11 (m, 1H), 7.10–7.03 (m, 1H), 6.96 (d, 1H, J=7.6 Hz), 4.80–4.73 (m, 1H), 4.62 (t, 1H, J=7.9 Hz), 4.09–4.04 (m, 1H), 3.51–3.42 (m, 1H), 3.03 (d, 2H, J=11.7 Hz), 2.82–2.72 (m, 1H), 2.51–2.42 (m, 2H), 2.32 (t, 2H, J=7.9 Hz), 2.11 (s, 1H), 2.03–1.97 (m, 2H) 1.85–1.70 (m, 4H), 1.49 (m, 4H), 1.31–1.27 (m, 1H), 1.24 (d, 6H, J=6.9 Hz); ESMS m/e: 514.4 (M+H)+.

Workup

customThe crude product was purified by preparative TLC

Sources & evidence

ORD record: ord-e9c12f7caa724e7bbf40da71283f23f7
Source dataset: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07067534B1

Reaction notes

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