Propionyl chloride → N-[4-(4-Piperidinyl)phenyl]propanamide

HRID 1832252Notes

Reaction equation

HRID 1832252 reaction equation
[CH3:1][CH:2](C)[C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[CH:8][CH:7]=1)=[O:4].NC1C=CC(C2CCN(C(OC(C)(C)C)=O)CC2)=CC=1.C(Cl)(=O)CC>>[NH:15]1[CH2:16][CH2:17][CH:12]([C:9]2[CH:10]=[CH:11][C:6]([NH:5][C:3](=[O:4])[CH2:2][CH3:1])=[CH:7][CH:8]=2)[CH2:13][CH2:14]1

Participants

4

Reactant 3

HCID 62324Propionyl chlorideHCID 21940085tert-Butyl 4-(4-aminophenyl)piperidine-1-carboxylateHCID 219572582-methyl-N-[4-(4-piperidinyl)phenyl]propanamide

Product 1

HCID 15342128N-[4-(4-Piperidinyl)phenyl]propanamide

Procedure

Prepared by the procedure for 2-methyl-N-[4-(4-piperidinyl)phenyl]propanamide using tert-butyl 4-(4-aminophenyl)-1-piperidinecarboxylate and propanoyl chloride: ESMS m/e: 233.1 (M+H)+.

Sources & evidence

ORD record
ord-09d2e37bdcf84db39e5620f3bc411a68
Source dataset
uspto-grants-2006_06
Patent number
US07067534B1

Reaction notes

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