4-Methyl-2-phenylpyrimidine-5-carbaldehyde → 2-Methyl-N-(3-{1-[(4-methyl-2-phenyl-5-pyrimidinyl)methyl]-4-piperidinyl}phenyl)propanamide

HRID 1832384Notes

Reaction equation

HRID 1832384 reaction equation
[CH3:1][C:2]1[C:7]([CH:8]=O)=[CH:6][N:5]=[C:4]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[N:3]=1.[CH3:16][CH:17]([CH3:33])[C:18]([NH:20][C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([CH:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)[CH:22]=1)=[O:19]>>[CH3:16][CH:17]([CH3:33])[C:18]([NH:20][C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([CH:27]2[CH2:32][CH2:31][N:30]([CH2:8][C:7]3[C:2]([CH3:1])=[N:3][C:4]([C:10]4[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=4)=[N:5][CH:6]=3)[CH2:29][CH2:28]2)[CH:22]=1)=[O:19]

Participants

3

Reactant 2

HCID 27765114-Methyl-2-phenylpyrimidine-5-carbaldehydeHCID 167572552-methyl-N-[3-(4-piperidyl)phenyl]propanamide

Product 1

HCID 220495082-Methyl-N-(3-{1-[(4-methyl-2-phenyl-5-pyrimidinyl)methyl]-4-piperidinyl}phenyl)propanamide

Procedure

Prepared by Procedure F and Scheme R using 4-methyl-2-phenyl-5-pyrimidinecarbaldehyde and 2-methyl-N-[3-(4-piperidinyl)phenyl]propanamide: ESMS m/e: 429.2 (M+H)+.

Workup

  1. customPrepared by Procedure F and Scheme R

Sources & evidence

ORD record
ord-881ca171928f4054af8e901e225695a8
Source dataset
uspto-grants-2006_06
Patent number
US07067534B1

Reaction notes

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