2,1,3-Benzothiadiazole-5-carbaldehyde → N-{3-[1-(2,1,3-Benzothiadiazol-5-ylmethyl)-4-piperidinyl]phenyl}-2-methylpropanamide

HRID 1832385Notes

Reaction equation

HRID 1832385 reaction equation
[N:1]1[S:2][N:3]=[C:4]2[CH:9]=[C:8]([CH:10]=O)[CH:7]=[CH:6][C:5]=12.[CH3:12][CH:13]([CH3:29])[C:14]([NH:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([CH:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)[CH:18]=1)=[O:15]>>[N:1]1[S:2][N:3]=[C:4]2[CH:9]=[C:8]([CH2:10][N:26]3[CH2:27][CH2:28][CH:23]([C:19]4[CH:18]=[C:17]([NH:16][C:14](=[O:15])[CH:13]([CH3:12])[CH3:29])[CH:22]=[CH:21][CH:20]=4)[CH2:24][CH2:25]3)[CH:7]=[CH:6][C:5]=12

Participants

3

Reactant 2

HCID 27762902,1,3-Benzothiadiazole-5-carbaldehydeHCID 167572552-methyl-N-[3-(4-piperidyl)phenyl]propanamide

Product 1

HCID 22049346N-{3-[1-(2,1,3-Benzothiadiazol-5-ylmethyl)-4-piperidinyl]phenyl}-2-methylpropanamide

Procedure

Prepared by Procedure F and Scheme R using 2,1,3-benzothiadiazole-5-carbaldehyde and 2-methyl-N-[3-(4-piperidinyl)phenyl]propanamide: ESMS m/e: 395.1 (M+H)+.

Workup

  1. customPrepared by Procedure F and Scheme R

Sources & evidence

ORD record
ord-6115e56678f64db2a89ff93725a11944
Source dataset
uspto-grants-2006_06
Patent number
US07067534B1

Reaction notes

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